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类器官Prostaglandin E2
类器官（Organoids）是指将成体干细胞或多能干细胞在体外三维培养形成的具有一定空间结构的组织类似物。类器官在组织结构、细胞类型、自我更新能力和功能等方面与来源组织高度一致，从而在发育生物学、疾病造模、精准医学、药物研发、基因和细胞疗法、感染和免疫以及再生医学等生物医学的多个领域展现出*的优势。
产品介绍DESCRIPTION
| Background | Prostaglandin E2 is a hormone-like substance that participate in a wide range of body functions such as the contraction and relaxation of smooth muscle, the dilation and constriction of blood vessels, control of blood pressure, and modulation of inflammation. |
| Alias | PGE2；前列腺素 E2；地诺前列酮 |
技术参数
| M. W t | 352.47 | |
| Formula | C₂₀H₃₂O₅ | |
| CAS No | 363-24-6 | |
| Storage | Powder | -20°C 3 years |
| In solvent | -80°C 6 months | |
| -20°C 1 month | ||
| Solubility | DMSO | ≥ 100 mg/mL(283.71 mM) |
| Ethanol | 70 mg/mL(198.60 mM) | |
| H2O | < 0.1 mg/mL(insoluble) | |
BIOLOGICAL ALTIVITY
In Vitro
PGE2 shows inhibition of IL 2 production in the mixture of irradiated and nonirradiated T lymphocytes. PGE2 (0.1-10 μM) dose-dependently inhibits the production of IL 2. PGE2 acts during the inductive phase of activation of suppressor cells. Preincubation of T lymphocytes with PGE2 induces cells that suppress IL 2 production and PHA proliferation[1].
In Vivo
PGE2 (0.3 μg/k, i.p.) significantly reduces the number of peritoneab macrophages undergoing phagocytosis of the methacrybate microbeads in rats[2]. PGE2 (0.1 mg/min, i.a.) increases renal blood flow. PGE2 produces a biphasic change in renal vascular resistance, vasodilatation starts at 0.01 mg/min and is maximal at about 3 mg/min, while at the highest dose used (20 mg/min) PGE2 induces renal vasoconstriction[3].
类器官Prostaglandin E2
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