类器官Hydrocortisone

简要描述:类器官Hydrocortisone
类器官(Organoids)是指将成体干细胞或多能干细胞在体外三维培养形成的具有一定空间结构的组织类似物。类器官在组织结构、细胞类型、自我更新能力和功能等方面与来源组织高度一致,从而在发育生物学、疾病造模、精准医学、药物研发、基因和细胞疗法、感染和免疫以及再生医学等生物医学的多个领域展现出*的优势。

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  • 更新时间:2023-11-07
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类器官Hydrocortisone类器官(Organoids)是指将成体干细胞或多能干细胞在体外三维培养形成的具有一定空间结构的组织类似物。类器官在组织结构、细胞类型、自我更新能力和功能等方面与来源组织高度一致,从而在发育生物学、疾病造模、精准医学、药物研发、基因和细胞疗法、感染和免疫以及再生医学等生物医学的多个领域展现出*的优势。

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DESCRIPTION


Background
Hydrocortisone is a steroid hormone or glucocorticoid secreted by the adrenal cortex[1].
AliasCortisol;氢化可的松17-羟基皮质 () 酮;皮质甾醇;氢化皮质素
M. W t362.46
FormulaC21H30O5
CAS No50-23-7
StoragePowder-20 °C         3 years
In solvent-80 °C   6 months
-20 °C         1 month                                      
SolubilityDMSO    
H2O : < 0.1 mg/mL
≥ 31 mg/mL(85.53 mM)

Ethanol23 mg/mL(63.46 mM)

H2O< 0.1 mg/mL(insoluble)

BIOLOGICAL ALTIVITY
In Vitro  
Hydrocortisone (50 nM) shows a dose-dependent down-regulation of GR transcript in hCMEC/D3 cells. Hydrocortisone supplementation of the serum-reduced cell differentiation medium leads to a significant increase in TER across the hCMEC/D3 monolayer[1]. Hydrocortisone-treated Dendritic cells (DCs) show a decreased expression of MHC II molecules, the costimulatory molecule CD86, and the DC-specific marker CD83, as well as a strongly reduced IL-12 secretion. Hydrocortisone-treated DCs inhibit production of IFN-γ but induce an increased release of IL-4 and no change in IL-5[2]. Hydrocortisone reduces postischemic oxidative stress, perfusion pressure, and transudate formation. Hydrocortisone inhibits postischemic shedding of syndecan-1, heparan sulfate, and hyaluronan as is release of histamine from resident mast cells[3].
In Vivo

NCT00621985Boston Children´s HospitalAdrenal Hyperplasia, CongenitalPhase 2
NCT03910088Cairo UniversityPost-Dural Puncture HeadachePhase 4
NCT00657306University of Turin, ItalyCirrhosis With AscitesPhase 2

类器官Hydrocortisone


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